ProLiant DL345 Gen12 Servers
The HPE ProLiant DL345 Gen12 is HPE's newest single-socket AMD EPYC 2U — current-generation cores with generous storage and I/O for data-centric workloads.
BYO HPE ProLiant DL345 Gen12 Server - 2U AMD EPYC Rack Server for Virtualization, AI, and Enterprise Workloads
The HPE ProLiant DL345 Gen12 Server is a powerful and flexible 2U rack server designed for organizations that need modern AMD EPYC performance, scalable DDR5 memory, PCIe Gen5 expansion, flexible storage options, and enterprise-class reliability. Built for virtualization, AI inference, analytics, databases, software-defined storage, backup infrastructure, private cloud, and demanding business workloads, the DL345 Gen12 delivers strong compute density and expansion flexibility in a practical 2U platform. This Build Your Own server allows you to configure the system with the processor, memory, storage, RAID, networking, GPU, and operating system options that best fit your environment.
Flexible 2U Rackmount Design
The HPE ProLiant DL345 Gen12 features a versatile 2U rackmount chassis designed for organizations that need a balance of compute performance, storage scalability, PCIe expansion, and serviceability. Its 2U design provides room for flexible drive layouts, enterprise networking, accelerator support, cooling, and accessible service components, making it a strong fit for data centers, managed service providers, SMB environments, branch offices, and growing enterprise infrastructures.
AMD EPYC Processor Performance
The HPE ProLiant DL345 Gen12 is powered by AMD EPYC processor technology, delivering strong core density, memory bandwidth, and efficient enterprise compute performance. As a single-socket AMD EPYC platform, the DL345 Gen12 is well suited for virtualization, analytics, AI inference, databases, application hosting, software-defined storage, backup infrastructure, and modern business workloads that benefit from powerful server-class performance in a scalable 2U platform.
DDR5 ECC Memory
The ProLiant DL345 Gen12 supports enterprise-grade DDR5 ECC server memory designed for improved bandwidth, stability, and reliable operation in production environments. ECC memory helps maintain data integrity and dependable system performance for virtualization, databases, analytics, AI workloads, caching, private cloud, and always-on business applications.
Flexible Storage Configurations
The HPE ProLiant DL345 Gen12 offers flexible storage configurations depending on the selected chassis and backplane. Available builds may support SAS, SATA, NVMe, SSD, and HDD storage options depending on configuration. This flexibility allows the DL345 Gen12 to be configured for virtualization storage, database workloads, software-defined storage, backup repositories, file services, high-speed application hosting, or mixed-use enterprise environments. HPE Smart Array RAID and HBA options can help provide storage performance, redundancy, and data protection for important workloads.
PCIe Gen5 Expansion and GPU Support
The DL345 Gen12 includes PCIe Gen5 expansion capability for compatible networking, storage controllers, GPUs, accelerators, and other PCIe-based hardware depending on the final build. PCIe Gen5 technology provides increased bandwidth for modern enterprise infrastructure, helping support high-speed networking, NVMe storage, AI acceleration, graphics workloads, and evolving enterprise I/O requirements.
Enterprise Network Connectivity
Reliable network connectivity is essential for modern IT infrastructure, and the HPE ProLiant DL345 Gen12 can be configured with embedded, OCP, and add-in network options depending on the system build. Whether used for virtualization traffic, storage networking, AI workloads, database access, analytics, web hosting, backup infrastructure, or production business applications, the DL345 Gen12 can be tailored with networking options that support the required level of throughput, redundancy, and scalability.
Remote Management with HPE iLO
The HPE ProLiant DL345 Gen12 includes HPE Integrated Lights-Out management technology for advanced remote server administration. HPE iLO allows administrators to remotely monitor system health, manage firmware, troubleshoot hardware, deploy updates, and access management tools from virtually anywhere. This helps improve uptime, reduce maintenance overhead, and simplify infrastructure management across distributed IT environments.
Security and Reliability
The ProLiant DL345 Gen12 is designed with HPE enterprise security and reliability technologies to help support dependable business operation. Depending on configuration, available features may include silicon root of trust, secure firmware protections, TPM support, platform monitoring, redundant power supplies, enterprise cooling, and secure remote management features. Combined with enterprise DDR5 ECC memory, RAID support, and server-grade engineering, the DL345 Gen12 is built to support production workloads with confidence.
Energy Efficiency and Serviceability
The HPE ProLiant DL345 Gen12 is engineered to deliver strong enterprise performance while maintaining efficient airflow, serviceability, and flexible deployment options in a 2U platform. Its chassis design supports accessible components, scalable storage layouts, PCIe expansion, and practical long-term maintainability for evolving IT infrastructures.
Ideal Use Cases
The HPE ProLiant DL345 Gen12 Server is best suited for:
- Virtualization: A scalable AMD EPYC platform for VMware, Hyper-V, Proxmox, and software-defined infrastructure environments.
- AI Inference and Accelerated Workloads: PCIe Gen5 expansion and GPU support make the system useful for AI inference, machine learning, and GPU-assisted applications depending on configuration.
- Database Workloads: Enterprise compute performance, DDR5 memory bandwidth, and flexible storage make the DL345 Gen12 suitable for databases and transactional systems.
- Software-Defined Storage: Flexible drive configurations and enterprise RAID or HBA options make the DL345 Gen12 useful for storage-heavy deployments.
- Backup and File Storage: Storage flexibility makes the system a strong fit for backup repositories, file sharing, and business data retention.
- Private Cloud Infrastructure: A dependable platform for private cloud, containers, orchestration platforms, and modern enterprise infrastructure.
- Business Application Hosting: A versatile enterprise server for analytics, internal applications, web services, and production workloads.
Conclusion
The HPE ProLiant DL345 Gen12 Server is a flexible and powerful 2U enterprise rack server built for organizations that need AMD EPYC performance, DDR5 memory, PCIe Gen5 expansion, flexible storage, remote management, and enterprise reliability. With scalable AMD EPYC processor support depending on build, enterprise DDR5 ECC memory, flexible SAS, SATA, SSD, HDD, and NVMe storage options, HPE Smart Array storage support, accelerator capability, and HPE iLO management, the DL345 Gen12 is well suited for virtualization, AI inference, databases, software-defined storage, backup infrastructure, private cloud, and general business workloads. Whether deployed in enterprise data centers, branch offices, managed service environments, or growing business networks, the HPE ProLiant DL345 Gen12 delivers dependable next-generation server performance in a scalable 2U platform.